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- _6 value "Figure 6 Notch function in cervical cancer. A theoretical model of how the tumour-suppressor properties of NOTCH1 can, in principle, be sidestepped in HPV-infected cervical cancer cells, allowing manifestation of growth-promoting properties of NOTCH1. Apart from HPV E6 and E7 proteins, cervical cancers frequently express increased levels of the phosphatidylinositol 3-kinase (PI3K) subunit p110? and ?Np63 as a result of amplification of the q26-29 locus of chromosome 3. Experiments show that Notch-induced PI3K confers resistance to anoikis in epithelial cells. Whether ERBB2 is induced by NOTCH in cervical cancer remains to be elucidated." provenance.
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