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- _3 value "Granuphilin was an effector of Rab27a, and its overexpression was reported to inhibit exocytosis of insulin granules (35?37). We recently reported that granuphilin promoter was a direct target of SREBP-1c and that the SREBP-1c/granuphilin pathway was a potential mechanism for impairment GSIS in diabetes, leading to ?-cell lipotoxicity (38). This key molecule of lipotoxicity was upregulated by palmitate and suppressed by palmitate-EPA at both mRNA and protein levels (supplemental Fig. 2A; Fig. 2D)." provenance.
- _3 wasQuotedFrom 18458149 provenance.