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- _4 value "When muscle is placed under stress or is damaged, the CRPs might signal to the nucleus to initiate repair through the activation ofmuscle-specific genes. In support of this hypothesis, CRP3/MLP seems to be a component of a Z-disc-localized stress sensor in cardiomyocytes, which, when it is defective, leads to the development of human dilated cardiomyopathy81. The response of cardiomyocytes to mechanical stress involves alterations in gene expression that lead to hypertrophy, and rats in which cardiac hypertrophy has been induced show a nuclear relocation of CRP3/MLP82. the theme of LIM proteins as connectors between the cytoskeleton and the nucleus." provenance.
- _4 wasQuotedFrom 15520811 provenance.