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- _2 value "metformin is as an activator of the AmPK?lKb1 pathway5,126. In liver, this results in inhibition of gluconeogenesis and hepatic glucose output, which in turn reduces circulating glucose level, resulting in a secondary decrease in insulin level. In transformed epithelial cells, metformin, similarly to other AmPK activators, inhibits rather than increases insulin-stimulated proliferation6,7." provenance.
- _2 wasQuotedFrom 19029956 provenance.