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- _6 value "Ang II?induced Rho/ROCK pathway activation require a tyrosine kinase, PYK2, and its upstream PKC- activation in VSMCs. PYK2 may signal to Rho through phosphorylation and activation of RhoGEF. In fact, PYK2 was coimmunoprecipitated with PDZ-RhoGEF on Ang II stimulation. PDZ-RhoGEF was tyrosine phosphorylated as well.32 Thus, Ang II activates Rho in VSMCs through PYK2 and PDZ-RhoGEF (Figure 2)." provenance.
- _6 wasQuotedFrom 16923993 provenance.