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- _6 value "Here we provide evidence that TGFbeta signalling prevents recruitment of Myc to the p15INK4b transcriptional initiator by Myc-interacting zinc-finger protein 1 (Miz-1). This relieves repression and enables transcriptional activation by a TGFbeta-induced Smad protein complex that recognizes an upstream p15INK4b promoter region and contacts Miz-1. (from Weinberg - Pathways in Human Cancer poster, SMAD = SMAD 2/3) (MIZ-1 = ZBTB17)" provenance.
- _6 wasQuotedFrom 11283614 provenance.