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- _5 value "<N15> DNA-PK is ADP ribosylated by PARP in vitro, and the protein kinase activity (including p53 and RPA substrates) is thereby stimulated (Ruscetti et al., 1998). (PARP is phosphorylated by DNA-PK [Ruscetti et al., 1998], but the consequences of this are unknown; therefore, this reaction is not included in the chart.) <N16> PARP is phosphorylated at a serine and a threonine site by PKCa and b in vitro, as a consequence of which PARP binding to DNA is weakened, and PARP activity is reduced (Bauer et al., 1992)." provenance.
- _5 wasQuotedFrom 10436023 provenance.