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- _7 value "At the leading edge of cells, Rac1 also links the adenomatous polyposis coli (APC) protein to actin filaments through binding to IQGAP1, thereby regulating polarization and directional migration by forming a complex with APC and CLIP-170. Of note, Nox2 also binds to and colocalizes with IQGAP1 at the leading edge in actively migrating ECs (Fig. 2)(50)." provenance.
- _7 wasQuotedFrom 17511588 provenance.