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- _6 value "Certain tumor cells exhibited high spontaneous adhesion and migration, which were attributable to a VEGF-dependent autocrine/paracrine activation of integrins. This activation was mediated by the VEGFR2 receptor and regulated via phosphatidylinositol-3-kinase, Akt, and the PTEN signaling axis Of the 22 integrin heterodimers, at least six, aVb3, aVb5, a5b1, a2b1, aVb1, and a1b1, have been implicated in angiogenesis" provenance.
- _6 wasQuotedFrom 11090623 provenance.