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- _4 value "We flanked the entire coding region of Shox2 with LoxP sites (10), such as to induce deletion upon exposure to the Cre recombinase (Fig. 1). Mice carrying such a floxed allele as well as a fully deleted copy and the limb-specific Prx1-Cre transgene (11) (hereafter referred to as Shox2 c/?) were thus devoid of any Shox2 transcript in their developing limbs (Fig. 1 b and c). We looked at Runx2 (mRNA) expression in Shox2 c/- mice, and, strikingly, very few Runx2-positive cells were scored in the humerus at E12.5 (Fig. 5 a)." provenance.
- _4 wasQuotedFrom 16537395 provenance.