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- _4 value "TPA induces phosphorylation of MEK1/2 on Ser-217/Ser-221 by PKC. TPA-induced phosphorylation of MEK1/2 is inhibited by PKC inhibitor H7, but not by GF109203X, which shows MEK activation depends on PKC isotype, which is distinct from that involved in SEK1-JNK activation in human colon cancer cells. Activated Ki-ras is not involved in MEK1/2-ERK pathway." provenance.
- _4 wasQuotedFrom 10344756 provenance.