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- _4 value "RAPA suppresses the functional activation of dendritic cells (DCs) both in vitro and in vivo.In vitro, RAPA inhibits IL-4-dependent maturation and T-cell stimulatory activity of murine bone marrow-derived DCs. These effects are associated with posttranscriptional down-regulation of both subunits of the IL-4 receptor complex (CD124, CD132) and are mediated via binding of RAPA to its intracellular receptor FK506-binding protein 12 (FKBP12)." provenance.
- _4 wasQuotedFrom 12531798 provenance.