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- _6 value "In addition, avb3 has been shown to bind MMP-2, in an RGD-independent way, thereby localizing MMP-2-mediated matrix degradation to the endothelial cell surface (28, 58). avb3 is nearly undetectable on quiescent endothelium, but is highly upregulated during cytokine or tumor-induced angiogenesis. In activated endothelium avb3 suppresses the activity of both p53 and the p53-inducible cell-cycle inhibitor p21WAF1/CIP1, while increasing the Bcl2:Bax ratio, resulting in an anti-apoptotic effect (226)." provenance.
- _6 wasQuotedFrom 11172729 provenance.