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- _4 value "increase in LDL oxidation enhances platelet activation via 2 independent pathways, 1 signaling via p38(MAPK) phosphorylation and 1 via Ca(2+) mobilization. Between 0% and 15% oxidation, the p38(MAPK) route enhances fibrinogen binding induced by thrombin receptor (PAR-1)-activating peptide (TRAP), and signaling via Ca(2+) is absent. At 30% oxidation, p38(MAPK) signaling increases further and is accompanied by Ca(2+) mobilization and platelet aggregation in the absence of a second agonist" provenance.
- _4 wasQuotedFrom 15692097 provenance.