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- _7 value "Fig. (4). Physical and functional interactions between components of the cell cycle and transcription factors. The cyclin D1/CDK4 complex is shown in relation to its substrate pRB. In addition, cyclin D1 binds to the HAT domain of P/CAF [10] and to the p160 coactivator SRC1 [15]. Cyclin D1 and cyclin E both regulate the cell cycle arrest function of BRG1 [178]. Cyclin D1 overcomes the BRCA1-mediated inhibition of liganded ER?. Cyclin E/CDK2 phosphorylates NPAT, which in turn contributes to the induction of histone expression" provenance.
- _7 wasQuotedFrom 15320717 provenance.