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- _5 value "Treatment of glEND.2 cells with vascular endothelial growth factor (VEGF, 10 ng/ml) induced a time dependent phosphorylation of ERK1/2, which was significant at 2 minutes of VEGF exposure (3.7 fold), peaking at 10 minutes, and thereafter tapering off. VEGF also induced activation of VEGFR-2. VEGF induced ERK1/2 activation was totally blocked by pretreatment with specific ERK1/2 inhibitor U0126. Inhibition of ERK1/2 activation also inhibited VEGF induced proliferation, where as inhibition of PKC or PI3K had no effect, suggesting that VEGF induces receptor mediated activation of ERK1/2 leading to proliferation in glEND.2 cells." provenance.
- _5 wasQuotedFrom 16039615 provenance.