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- _4 value "Figure 5. Regulation of the core cell-death machinery by E2F-1 and the p53 family. E2F-1 can regulate apoptosis in many ways. It can induce cell death by stabilizing the levels of p53 through activating the ARF tumor suppressor, which suppresses Mdm2, a negative regulator of p53. The p53 protein regulates the transcription of several celldeath genes including BH3-only proteins, proapoptotic Bcl-2 protein Bax and the caspase-9 adaptor Apaf-1. In cells lacking p53, E2F-1 can act through p73, a member of p53 family that activates some of the same target genes as p53. E2F-1 can also directly regulate the transcription of several different caspases and suppress cell survival pathways by suppressing Mcl-1 expression or by inhibiting NFkB-mediated antiapoptotic signaling." provenance.
- _4 wasQuotedFrom 15082313 provenance.