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- _5 value "In contrast to these factors that all bind to the ER LBD, some coactivators, such as the steroid receptor RNA activator SRA and the RNA helicases p68/p72, interact with and regulate the AF-1 domain of ER [48-50]. GT198, a tissue-specific and kinase-regulated coactivator, interacts with the ER DNA-binding domain. GT198 differs from other coactivators in that it regulates basal receptor activity and hormone sensitivity [51]." provenance.
- _5 wasQuotedFrom 14680484 provenance.