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- _4 value "the oncogenic effects of Notch include phosphatidylinositol 3-kinase (PI3K) activation and induction of ERBB2 and NF-?B2 expression. The mechanism by which PI3K is activated by NOTCH1-IC is not known, but the induction of ERBB2 and NF-?B2 - the promoters of which contain CSL-binding sites - is almost certainly mediated by the transactivation function of NOTCH1-IC. PI3K signalling confers resistance to anoikis 80,81 and p53-mediated apoptosis 82, whereas ERBB2 stimulates proliferation and growth of cells." provenance.
- _4 wasQuotedFrom 14570040 provenance.