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- _3 value "Figure 7. MPO-positive macrophages in vitro produce HOCl in response to atherogenic stimuli...The cells chlorinated extracellular taurine in response to PMA and to opsonized zymosan (Figure 7) and PMA provoked MPO release from macrophages, presumably by degranulation (medium MPO levels: vehicle, 1.0 6 0.2; PMA, 21.2 6 3.1 ng/ml; n 5 3; P , 0.01). Pathophysiological stimuli known to be present in human atherosclerotic plaques, CD40L,33 lysoPC,34 or cholesterol crystals,30 induced HOCl-release from GM-CSFtreated macrophages (Figure 7) and MPO release from macrophages in vitro (medium MPO levels: vehicle, 1.0 6 0.2; CD40L, 17.5 6 2.6; cholesterol crystals, 12.1 6 1.8; lysoPC, 14.8 6 2.2 ng/ml; n 5 3; P , 0.01)." provenance.
- _3 wasQuotedFrom 11238037 provenance.