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- _5 value "Activated Rac promotes recruitment of highaffinity integrins aVh3 to lamellipodia [92] and the establishment of new adhesions at the leading edge, which are essential for directional cell migration. Furthermore, integrin-specific activation of Rac by a5h1 promotes endothelial cell proliferation on fibronectin through the induction of cyclin D1 synthesis via a Shc-FAK-SOS-PI-3K-dependent signaling [93]." provenance.
- _5 wasQuotedFrom 14984767 provenance.