Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RAUOqFQHgP5oCsBqh99qPE-q0y0ru_Ej9eXsjupbZhfoY#_7> ?p ?o ?g. }
Showing items 1 to 2 of
2
with 100 items per page.
- _7 value "Both B-Raf and C-Raf can bind to other small GTPases, most notably Rap1.115,131,132 The effector domains of Rap1 and Ras are nearly identical, but activation of these proteins produces vastly different downstream effects. Furthermore, Rap1 mediates distinct effects after binding to various Raf isoforms. The B-Raf?Rap1 complex activates B-Raf, whereas the C-Raf?Rap1 interaction does not activate C-Raf and, in fact, may be inhibitory.115,132,133 This occurs because Rap1 binds to the CRD of C-Raf with higher affinity than Ras and excludes Ras from binding." provenance.
- _7 wasQuotedFrom 16170185 provenance.