Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RAUrIYPtUz4NrWzwUCMfKVcUJ-o9uIYudQCWy9yuIhQKU#_3> ?p ?o ?g. }
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- _3 value "we show here that there exists a dynamic feedback loop that is triggered by a DNA damage response (DDR) and, which after a delay of several days, locks the cell into an actively maintained state of 'deep' cellular senescence. The essential feature of the loop is that long-term activation of the checkpoint gene CDKN1A (p21) induces mitochondrial dysfunction and production of reactive oxygen species (ROS) through serial signalling through GADD45-MAPK14(p38MAPK)-GRB2-TGFBR2-TGFbeta. These ROS in turn replenish short-lived DNA damage foci and maintain an ongoing DDR." provenance.
- _3 wasQuotedFrom 20160708 provenance.