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- _6 value "STAT3 can also cooperate with AKT or MYC to downregulate p21WAF1 expression and prevent cell-cycle arrest or senescence [55,56]. Interestingly, it has also been recently shown that the SRC STAT3 oncogenic pathwaymight inhibit the expression of the p53 gene. Following its activation by the SRC kinase, STAT3 binds to the promoter of the tumor suppressor gene and prevents its expression. STAT3 downregulates the p53 promoter in breast-cancer cells" provenance.
- _6 wasQuotedFrom 17118707 provenance.