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- _6 value "Jurkat transfectants overexpressing Chat-H show a marked increase in interleukin-2 production after costimulation of T cell receptor and CD28. The degree of JNK activation is enhanced substantially in the Chat-H transfectants upon costimulation. WE found that Chat-H forms a complex with Pyk2H and enhances its tyrosine 402 phosphorylation, an up-regulator of the JNK pathway. The Src homology-2 domain mutant of Chat-H loses this signal modulating activity." provenance.
- _6 wasQuotedFrom 12486027 provenance.