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- _5 value "Promoter fragments that contain either 2 or 6 kb of 5' flanking region of mouse PGC-1? both are activated at least 3-fold by the expression of constitutively active CaMKIV (Fig. 1A). In contrast, expression of a constitutively active CnA has very little effect on reporter gene activity, consistent with the results obtained previously for PGC-1? mRNA expression in CaMKIV and CnA transgenic mice (11). However, the combination of CaMKIV and CnA has a powerful effect on the PGC-1? promoter, increasing transcription by ~7-fold (Fig. 1A)." provenance.
- _5 wasQuotedFrom 12764228 provenance.