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- _3 value "In contrast, anti-CD3 mAb stimulation without exogenous IL-12 induced a large amount of IFN-{gamma} (68.5 (5.0) ng/ml), as well as marked expression of T-bet (fig 3AGo?C). The level of T-bet induction by anti-CD3 mAb stimulation was not significantly different among CD4+ PBMCs from CD or UC patients, or NL (fig 3BGo). Consistent with mRNA expression, T-bet protein was augmented by anti-CD3 mAb stimulation in CD4+ PBMCs from patients with CD (fig 3CGo; similarly in UC and NL, but data not shown). Furthermore, in parallel with T-bet induction by anti-CD3 mAb stimulation, IL-12R�2 was also induced in CD4+ PBMCs (fig 3DGo) and additional stimulation by IL-12 induced a fivefold greater amount of IFN-{gamma} (355.0 (62.2) ng/ml) than anti-CD3 mAb stimulation alone (fig 3AGo). " provenance.
- _3 wasQuotedFrom 15306590 provenance.