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- _5 value "It has been shown recently that ubiquitination plays an important role in TAK1 activation (26, 27). IKK activation by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex composed of Ubc13 and Uev1A as well as the TAK1�kinase complex. TRAF6 can interact through its RING finger domain with Ubc13 in the Ubc13�Uev1A complex. This Ubc�TRAF6 complex catalyzes the formation of a Lys-63-linked polyubiquitin chain, which triggers TAK1 activation through a unique proteasome-independent mechanism." provenance.
- _5 wasQuotedFrom 12893815 provenance.