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- _3 value "Chung (48, 49) summarized in detail the cytokines overexpressed in COPD (48, 49). IL-6, IL-1beta, TNF-{alpha}, growth-related gene-{alpha} (Gro-{alpha})/keratinocyte-derived chemokine (KC) (CXCL1), monocyte chemoattractant protein-1 (MCP-1), and IL-8 were increased in sputum, with further increases during exacerbations of COPD, and the bronchiolar epithelium overexpressed MCP-1, its receptor CCR2, MIP1{alpha}, and IL-8. MCP-1 and CCR2 were involved in the recruitment of macrophages and mast cells into the airway epithelium in COPD (62)." provenance.
- _3 wasQuotedFrom 17615396 provenance.