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- _4 value "PC12 cells were grown on collagenI, collagenIV, or Laminin after a 48 hour incubation in media lacking serum with or without NGF(50ng/ml). To this KP-392 (ILK inhibitor) 100 microM was added. This resulted in Tau hyperphosphorylation. Moreover it was found that ILK colocalized with beta1 integrin in cerebellar granule neurons.These results demonstrated that ILK was activated by Integrin and NGF receptor stimulation and when inhibited leads to tau hyperphosphorylation." provenance.
- _4 wasQuotedFrom 12629168 provenance.