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- _5 value "The fact that CXCR4 is a hypoxia-inducible gene provided a potential mechanistic explanation for CXCR4 upregulation during tumour cell evolution. CXCR4- induced cell-surface expression due to the loss of VHL function confers enhanced migratory potential to RCC cells in response to its cognate ligand stromal-derived factor 1 (SDF1)." provenance.
- _5 wasQuotedFrom 15350900 provenance.