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- _6 value "The IRAK4:IRAK1:TRAF6 complex then interacts at the membrane with another preformed complex consisting of TAK1, TAB1 and TAB2. This interaction induces phosphorylation of TAB2 and TAK1. TAK1 is subsuequently activated in the cytoplasm, leading to the activation of IKK. Activation leads to phosphorylation and degradation of IKB and consequent release of NFKB. Activation of TAK1 also results in the activation of MAP kinases and JNK." provenance.
- _6 wasQuotedFrom 12893815 provenance.