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- _3 value "Nicotine or NNK (100 nM) increased proliferation ~2-fold in both cell lines. Immunoblotting analysis revealed that after daily administration of nicotine or NNK, Akt activation increased 41.5- fold in both cell lines. The reasons for the less robust increase in Akt activation on day 3 is unclear, but might be related to the higher dose (10 mM) or longer time course (5 days) used in Figure 4A. Increased NSCLC cell proliferation was associated with increased cyclin D1 expression" provenance.
- _3 wasQuotedFrom 15790591 provenance.