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- _8 value "from full text - Smad2 and Smad3 are bound to SARA (SMAD anchor for receptor activation) in the cytoplasm (Tsukazaki et al., 1998) which presents Smad2 and Smad3 to the activated TGF-b receptor complex. TbRI then directly phosphorylates the carboxy terminal of Smad2 and Smad3, resulting in decreased affinity to SARA and heterotrimerization of Smad2 and Smad3 with Smad4 (SARA = ZFYVE9) " provenance.
- _8 wasQuotedFrom 15715939 provenance.