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- _6 value "Repair mechanisms activated by ROS-induced DNA damage require cell cycle arrest, which is mediated by several damage checkpoints (Abraham 2001). Following recognition of DNA damage by PARP-1, a simultaneous 9-1-1 ?alert? complex is formed, consisting of Rad9, Rad1 and Hus1, which are activated under the control of Rad17 to initiate a downstream DNA damage-signaling cascade (Figure 1) (Melo et al., 2001; Kondo et al., 2001)." provenance.
- _6 wasQuotedFrom 18208352 provenance.