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- _6 value "F ig. 2. Effect of Toll-like receptor signalling on macrophage cholesterol metabolism. Stimulation of TLR3 or TLR4 leads to TRIFdependent activation of IRF3, which inhibits transcription of liver X receptor-dependent genes, many of which (e.g. ATP-binding cassette transporter A1, PLTP, apoE and ABCG-1) are critically involved in the efflux of cholesterol from macrophages. " provenance.
- _6 wasQuotedFrom 20375591 provenance.