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- _3 value "Relative to wild-type mice, lung hyperpermeability, inflammation, and epithelial cell injury were enhanced in Nrf2?/?mice (Cho et al., 2002a). Consistentwith a protective role for the Nrf2-ARE pathway during lung toxicity by hyperoxia,Nrf2?DNAbinding activity and expression of multiple antioxidant enzymes (e.g., GSTs, NQO1, UDP-glucuronyl transferase [UGT], GCLc, GCLm, HO-1, GPx2) were markedly suppressed in Nrf2?/? mice." provenance.
- _3 wasQuotedFrom 19646463 provenance.