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{ <http://www.tkuhn.ch/bel2nanopub/RAWstbV6lPhaVcgMGBjaPgAo5-pwkUpTfBcSEwlmr5qWY#_5> ?p ?o ?g. }
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The most critical regulatory event in NF-{kappa}B activation is site-specific phosphorylation of I{kappa}B ({alpha}, beta, and {varepsilon}) by the IKK complex, which leads to polyubiquitination and proteasomal degradation.
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