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- _5 value "Previous studies have demonstrated a role for cyclin D1 in the repression of several distinct transcription factors (Fig. 4). In addition to binding CDK4, CDK6, and pRB, cyclin D1 forms physical associations with P/CAF (p300/CB P associated factor), Myb, MyoD, and the cyclin D1 myb-like binding protein (DMP1) [8-11]. Cyclin D1 and D2 are capable of inhibiting MyoD [12]. v-Myb is preferentially repressed by cyclin D1 [9], although cyclin D2 and D3 are also capable of repressing v-Myb; the helix-loop-helix-like protein DMP1 is repressed by each of the D-type cyclins [8]. In contrast, the repression of BETA2/NeuroD by cyclin D1 is not reconstituted by either cyclin D2 or D3." provenance.
- _5 wasQuotedFrom 15320717 provenance.