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- _6 value "Furthermore, skeletal myotube hypertrophy induced by IG1 could be inhibited by a pharmacological inhibitor of PI3K . Therefore, PI3K activity is necessary for IGF1 to induce hypertrophy, and its activation is sufficient to induce hypertrophy. For example, knockout mice that are Akt2 are normal in size but have a diabetic phenotype because of insulin resistance . The PI3K Akt2 pathway has been linked to glucose transport via the Glut4 transporter" provenance.
- _6 wasQuotedFrom 12928036 provenance.