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- _5 value "Insulin resistance in type 2 diabetes is partly due to impaired glucose transport in skeletal muscle. Atypical protein kinase C (aPKC) and protein kinase B (PKB), operating downstream of phosphatidylinositol (PI) 3-kinase and its lipid product, PI-3,4,5-(PO(4))(3) (PIP(3)), apparently mediate insulin effects on glucose transport. insulin receptor substrate (IRS)-1-dependent PI 3-kinase" provenance.
- _5 wasQuotedFrom 12882907 provenance.