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- _3 value "MuRF1 -/- and MAFbx -/- mice appear phenotypically normal. However, under atrophy conditions, significantly less muscle mass is lost in either MuRF1 -/- or MAFbx -/- animals in comparison with control littermates [11]. Myostatin However, when muscle obtained from myostatin -/- animals was analyzed, it was shown to be larger as a result of an increase in the number of muscle fibers, and not as a result of hypertrophy. Therefore, it was thought that myostatin acts in a way that is distinct from the activation of atrophy or the inhibition of hypertrophy; that it simply blocks the proliferation of muscle precursors, thus decreasing muscle mass." provenance.
- _3 wasQuotedFrom 12928036 provenance.