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- _4 value "COX-2 inhibitors can also activate prosurvival pathways. The PI3K/Akt pathway is a survival pathway, frequently activated in cancer cells [49]. PI3K produces PIP3 (phosphatidylinositol 3,4,5 triphosphate) that activates PDK1 (pyruvate deshydrogenase kinase). This protein phosphorylates and activates PKB (protein kinase B), which, in turn, is responsible for the phosphorylation of several targets playing a modulator function in apoptosis. An anti-cancer effect of celecoxib due to the inhibition of Akt signaling [111] was observed in a gastric cancer model. " provenance.
- _4 wasQuotedFrom 20339581 provenance.