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- _6 value "While the activity of these enzymes in the newborn PEX2-/- mouse liver was normal, all enzyme activities were significantly elevated in the postnatal knockout mouse livers (Fig. 1A to D). The pattern observed in PEX2 knockout mice differed markedly, with enzyme activity continuing to increase in postnatal PEX2-/- mice. For example, HMG-CoA reductase {HMGCR} activity was increased 5-fold at P3-5 and 10-fold at P7-10 in knockout mice (Fig. 1A). Activities of IPP isomerase, {IDI1} FPP synthase {FDPS}, and squalene synthase {FDFT1} were increased twofold at P3-5 in PEX2-/- mice (Fig. 1B to D). At P7-10, the activities of FPP synthase and squalene synthase were increased 10-fold in mutant mice while IPP isomerase activity was increased 18-fold. " provenance.
- _6 wasQuotedFrom 14673138 provenance.