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- _5 value "Vasoactive intestinal peptide binding to VPAC(2) on CD4 T cells specifically induces an up-regulation of the Th2-type transcription factors c-Maf and JunB, which consequently enhances IL-4 and IL-5 production, leading to a Th2-type phenotype. There is strong evidence to support requirements for c-Maf, JunB, and NFAT in promoting IL-4 production. JunB, a member of the AP-1 transcription factor family, acts synergistically with c-maf to strongly activate IL-4 expression, and has also been shown to be required for IL-5 expression in Th2 cells (17, 29)." provenance.
- _5 wasQuotedFrom 15187104 provenance.