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- _5 value "Three groups have reported that Cyclin E ubiquitinylation is mediated by the ubiquitin ligase SCFFbw7 The interaction between Fbw7 and Cyclin E is phosphorylation dependent since mutation on two residues phosphorylated by Cdk2 impairs Cyclin E ability to bind Fbw7. Furthermore, SCFFbw7 is able to ubiquitinylate Cyclin E in a phosphorylation-dependent manner in vitro." provenance.
- _5 wasQuotedFrom 15021891 provenance.