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- _3 value "Bhowmick et al. (2004) generated mice with a targeted deletion of TGFBRII in fibroblasts. Such loss of TGF? signaling in the prostate and the forestomach resulted in hyperplasia of the adjacent epithelia with progression to prostatic intraepithelial neoplasia and gastric squamous carcinoma, respectively (Figure 7A). These effects were accompanied by an elevated expression of hepatocyte growth factor (HGF) in the TGFBRII-defective fibroblasts and activation of the HGF receptor Met in adjacent epithelial cells." provenance.
- _3 wasQuotedFrom 18662538 provenance.