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- _5 value "PU.1 and Spi-B directly regulate the expression of several genes associated with BCR signaling such as BLNK, B220, Btk, P2Y10, and Grap2 [10, 29?32].Spi-C has DNA-binding specificity identical to PU.1 and Spi-B and therefore might regulate many of the same genes as these transcription factors [25].The levels of BLNK, Lyn, B220, Btk, and P2Y10 transcripts were significantly decreased in bone marrow pre-B and immature B cells enriched from Spi-C transgenic mice compared with the wild type. In contrast, Grap2 was increased in transgenic Spi-C pre-B cells compared with wild type (Real time RT-PCR analysis, n = 3)" provenance.
- _5 wasQuotedFrom 18792411 provenance.