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- _3 value "Treatment of ASK1+/+ MEFs with an antioxidant, N-acetyl-L-Cysteine (Nac) resulted in the inhibition of TNF induced apoptosis similar to that observed in ASK1-/- MEFs and Nac effectively inhibited only the sustained phases of TNF induced JNK/p38 activation in ASK1+/+ MEFs. This suggests that TNF induced apoptosis was H2O2 dependent via ASK1/JNK/p38 or H2O2 independent by caspase 8 pathway." provenance.
- _3 wasQuotedFrom 11266364 provenance.