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- _5 value "Gangliosides bind FGF1, FGF2, and FGF4 via negatively charged Neu-Ac residues [147,148]. In the extracellular environment, gangliosides compete with free heparin for the binding to the growth factor. On endothelial cells, free gangliosides prevent the binding of FGF2 to FGFRs and HSPGs, thus inhibiting FGF2-mediated cell proliferation [147]. Ganglioside GM1 is expressed on the endothelial cell surface and binds FGF2 with an affinity that is significantly higher than that of its free counterpart (Table 1). Under these conditions, GM1 acts as a functional FGF2 co-receptor." provenance.
- _5 wasQuotedFrom 15863032 provenance.